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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K3
All Species:
22.42
Human Site:
T273
Identified Species:
41.11
UniProt:
P46734
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46734
NP_002747.2
347
39318
T273
F
P
Y
E
S
W
G
T
P
F
Q
Q
L
K
Q
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
A309
M
D
S
R
P
P
M
A
I
F
E
L
L
D
Y
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546666
347
39324
T273
F
P
Y
E
S
W
G
T
P
F
Q
Q
L
K
Q
Cat
Felis silvestris
Mouse
Mus musculus
O09110
347
39278
T273
F
P
Y
E
S
W
G
T
P
F
Q
Q
L
K
Q
Rat
Rattus norvegicus
Q4KSH7
419
47517
T327
F
P
Y
K
N
C
K
T
D
F
E
V
L
T
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
T278
F
P
Y
E
S
W
G
T
P
F
Q
Q
L
K
Q
Chicken
Gallus gallus
Q90891
398
44059
A315
M
D
S
R
P
A
M
A
I
F
E
L
L
D
Y
Frog
Xenopus laevis
Q07192
446
50082
S359
F
P
Y
P
K
W
N
S
V
F
D
Q
L
T
Q
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
S286
I
L
R
F
P
Y
D
S
W
G
T
P
F
Q
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
R261
R
T
P
F
E
Q
L
R
Q
V
V
E
D
S
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
D277
Q
E
W
N
S
L
F
D
Q
I
A
T
V
V
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
S279
E
D
Q
Q
N
P
P
S
F
Y
E
L
L
A
A
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
N571
Y
P
P
E
T
Y
D
N
I
F
S
Q
L
S
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
30.7
N.A.
99.1
N.A.
96.5
37.2
N.A.
89.7
30.3
42.1
75.3
N.A.
57
N.A.
37.7
N.A.
Protein Similarity:
100
47
N.A.
99.7
N.A.
98.8
56.7
N.A.
93.1
48.7
58
84.4
N.A.
72.9
N.A.
55.6
N.A.
P-Site Identity:
100
13.3
N.A.
100
N.A.
100
40
N.A.
100
13.3
53.3
6.6
N.A.
0
N.A.
6.6
N.A.
P-Site Similarity:
100
20
N.A.
100
N.A.
100
66.6
N.A.
100
20
60
26.6
N.A.
6.6
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.7
23.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.2
35.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
16
0
0
8
0
0
8
16
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
24
0
0
0
0
16
8
8
0
8
0
8
16
0
% D
% Glu:
8
8
0
39
8
0
0
0
0
0
31
8
0
0
0
% E
% Phe:
47
0
0
16
0
0
8
0
8
70
0
0
8
0
0
% F
% Gly:
0
0
0
0
0
0
31
0
0
8
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
24
8
0
0
0
0
0
% I
% Lys:
0
0
0
8
8
0
8
0
0
0
0
0
0
31
8
% K
% Leu:
0
8
0
0
0
8
8
0
0
0
0
24
77
0
0
% L
% Met:
16
0
0
0
0
0
16
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
16
0
8
8
0
0
0
0
0
0
0
% N
% Pro:
0
54
16
8
24
16
8
0
31
0
0
8
0
0
8
% P
% Gln:
8
0
8
8
0
8
0
0
16
0
31
47
0
8
47
% Q
% Arg:
8
0
8
16
0
0
0
8
0
0
0
0
0
0
0
% R
% Ser:
0
0
16
0
39
0
0
24
0
0
8
0
0
16
8
% S
% Thr:
0
8
0
0
8
0
0
39
0
0
8
8
0
16
0
% T
% Val:
0
0
0
0
0
0
0
0
8
8
8
8
8
8
0
% V
% Trp:
0
0
8
0
0
39
0
0
8
0
0
0
0
0
0
% W
% Tyr:
8
0
47
0
0
16
0
0
0
8
0
0
0
0
16
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _